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Comparative studies

Comparison of 1 and 2 dose vaccination regimens using three currently licensed Mycoplasma hyopneumoniae vaccines in pigs

A side by side, blinded, laboratory challenge study involving 5 groups of pigs, in order to compare the efficacy of Ingelvac MycoFLEX® (1ml @ 3 wks), single dose mineral oil-based Mycoplasma hyopneumoniae vaccine ("Vaccine S") (2mls @ 3 wks) and two dose mineral oil-based Mycoplasma hyopneumoniae vaccine ("Vaccine T") (2mls @ 1 wk and 3 wks), non-vaccinated, non-challenged pigs (NVNC) and non-vaccinated, challenged (NVC) pigs. Pigs were kept in groups of 50 per treatment group. At 9 weeks of age, excepting the NVNC group, all groups were challenged with a virulent Mycoplasma hyopneumoniae homogenate. All pigs were euthanized, had necropsies performed and all lungs were scored on day 28 post challenge.

The non-vaccinated, non-challenged group had a significantly lower average ‘% lung lesion’ score than the non-vaccinated, challenged group (0.8 vs. 11.8).
Ingelvac MycoFLEX® and "Vaccine T" (2 dose) groups had significantly lower average % lung lesion scores than the non-vaccinated, challenged (NVC) group. "Vaccine S" scores were not significantly different to the NVC group.

Ingelvac MycoFLEX® provided a significant reduction in lung pathology due to Mycoplasma hyopneumoniae, compared to non-vaccinated, challenged control pigs, and was as effective as other commercially available vaccines.

Baysinger A, Polson D, Edler R, Philips R, Diaz E. Comparison of 1 and 2 dose vaccination regimens using three currently licensed Mycoplasma hyopneumoniae vaccines in pigs. Proc Allen D Leman Swine Conference, 2008