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Key research

Safety and side effects

A Laboratory Evaluation of the Comparative Injection Site Tissue Reactivity of PCV2 Vaccines

Forty-eight weaned feeder pigs, approximately 18 to 21 days of age, were randomly allocated to three treatment groups (n=16 per group) in a blinded, internal control study. Piglets were vaccinated according to manufacturer's instructions with either Ingelvac CircoFLEX®, another one dose commercial vaccine, and a two dose commercial vaccine. A saline injection of equal volume was made on the opposite side of the neck to serve as an internal control. Piglets were humanely euthanized 14 days following the final injection (first dose for one dose vaccines, second dose for the two dose vaccine). An injection site tissue sample was harvested, processed and blindly scored for both intramuscular and connective tissue lesions.

There was no significant difference in either muscle or connective tissue lesion scores between Ingelvac CircoFLEX® and saline control. In contrast both the other vaccines produced significantly higher lesion scores in both muscle and connective tissue than either saline control (p<0.01) or Ingelvac CircoFLEX® (p<0.001).

Kolb J. Diaz E, Christmas R. A laboratory evaluation of the comparative injection Site Tissue Reactivity of PCV2 Vaccines. IPVS 2008


Comparative Safety of PCV2 Vaccines under Normal Conditions of Use

3 groups of 300 pigs were vaccinated, each with one of the 3 piglet vaccines currently commercially available in the USA. 20 pigs from each group were individually examined at 14 days post final injection. After examination and humane euthanasia, injection sites were examined.

Injection sites from pigs vaccinated with Ingelvac CircoFLEX® were not different from saline injected sites. Significant lesions were noted following injection of both the other piglet vaccines used.

Petersen B et al. Comparative safety of PCV2 vaccines under normal conditions of use. IPVS 2008


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